Vampires will be easier to deal with than zombies. I watched large chunks of Buffy...
She was doing it wrong. Undead or not, it still goes down if you hit it hard enough with a big enough vehicle.
I firmly disagree. A zombie hoard can be fought because they are stupid and disorganized. A vampire menace is a completely different beast. Vampires are typically thought to be
at least as intelligent as humans. There is no effective defense against an organized assault by even a small group of vampires. (By small I mean, maybe 10 vampires per 100-200 humans.)
Consider that they are able to utilize every weapon we can, and every tactic we know against us. Including psychological warfare. Further, lacking heartbeat and respiration, they would be truly unrivaled in stealth and ambush tactics.
All of that isn't even taking varying mythologies into account. Traditionally, vampires have no problem with sunlight, it was a weakness thought up by Murnau while he was trying rewrite the script for Nosferatu to slip around copyright infringement on Stoker's work. Regardless all they would need is a bit of good planning to a daytime resting place and a bit of care to ensure they're not followed when returning.
Even if you could hold a vampire at bay with a cross, if they simply worked in teams, they could easily surprise and take an cross bearing humans from behind.
They might have trouble crossing running water, but bridges abound, and airplanes and helicopters aren't that hard to find these days.
If crosses and blessed things can hold them at bay, you might try hiding in a church, but they'd probably just lob a grenade in through the stained glass window.
We've put a lot of work into zombie planning, but when we attempted to plan for a vampire attack, we quickly realized there are only three options. 1.) Flee. 2.) Suicide 3.) Join the vampires.