Playing a right handed guitar seems entirely sensible to me. I have one friend who's right handed who plays left handed guitars which again seems sensible.
There are two schools of thought supporting left-handed individuals playing right-handed instruments. One believes that using the left hand as the "fretting" hand is a better use of its strengths, while the other bases its support on the poor availability of left-handed instruments.
I personally stand against both schools, but I do agree that playing right-handed as a lefty does present some advantages. However, the flip side of the coin is not without its perks. Personal experience has taught me that playing left-handed guitars as a lefty has several benefits not enjoyed by those who do otherwise:
- My "fretting hand" is my right hand, encouraging the development of its strength and dexterity.
- My "plucking hand" is my left hand, allowing me to take advantage of its strengths for faster playing, steadier rhythm, and greater control of dynamics.
- My purchase of a left-handed instrument encourages manufacturers to continue to provide quality left-handed instruments and even expand their offerings by contributing to the existence of the left-handed instrument musician's market.
Understand this, my fellow southpaw musicians: the reason why it's so hard to find a good midrange instrument is not simply because we represent 10-15% of the market - after all, plenty of these manufacturers make instruments which only a meager handful of musicians worldwide would even think of buying, some of which are outright gimmicky and will sell poorly. Our reluctance to actually pursue a left-handed instrument causes the lefty instrument market to suffer, and compounds the difficulties of those of us who DO intend to play left-handed.
Long story short, it's a collective action problem. The more of us that buy lefty instruments, the better off we'll be in the long run. Trouble is, the short run sucks - the early adopters will have to live with the limited selection.
I have to ask, which hand do you lefties use for your mouse? I got into all sorts of problems assuming my left hand would be the best for it. Couldn't get the hang of it at all 'til I started to use my right hand 
I'm ambidextrous with mouse operation and switch up depending on the activity. I usually opt for hand-neutral mice for this reason, although I'd love to have a left-handed mouse on-hand for certain tasks. Intrerestingly enough, I used mice with my right hand for most of my life. It seemed comfortable because I could type easily with my left hand, and it wasn't too difficult to train my right hand to maneuver the mouse. However, in overall performance and ability, the left hand wins. If it weren't for the poor typing ability of my right hand when flying solo, I'd use my left hand on the mouse for all tasks.
